Drug interactions
Eslicarbazepine + Pentamidine
Severity: Minor
Eslicarbazepine and Pentamidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine could modestly raise systemic pentamidine exposure. The clinical relevance is uncertain and based on a theoretical mechanism.
What this interaction means in plain words
Eslicarbazepine and Pentamidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.
Why it happens
Possible CYP2C19 inhibition by eslicarbazepine reduces pentamidine metabolism.
What to do
Monitor for pentamidine toxicity such as hypoglycemia, hypotension and QT prolongation during systemic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Eslicarbazepine with Pentamidine?
MediHelp rates the interaction as minor. Eslicarbazepine and Pentamidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine could modestly raise systemic pentamidine exposure. The clinical relevance is uncertain and based on a theoretical mechanism.
How serious is the interaction between Eslicarbazepine and Pentamidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pentamidine toxicity such as hypoglycemia, hypotension and QT prolongation during systemic therapy.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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