Drug interactions
Eslicarbazepine + Ubrogepant
Severity: Moderate
Eslicarbazepine and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower ubrogepant exposure and reduce its efficacy for acute migraine. Ubrogepant labeling advises dose adjustment with CYP3A4 inducers.
What this interaction means in plain words
Eslicarbazepine and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Ubrogepant belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases the metabolism of ubrogepant.
What to do
Follow the labeled dose increase for ubrogepant with CYP3A4 inducers, and monitor migraine response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Eslicarbazepine with Ubrogepant?
MediHelp rates the interaction as moderate. Eslicarbazepine and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may lower ubrogepant exposure and reduce its efficacy for acute migraine. Ubrogepant labeling advises dose adjustment with CYP3A4 inducers.
How serious is the interaction between Eslicarbazepine and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the labeled dose increase for ubrogepant with CYP3A4 inducers, and monitor migraine response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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