Drug interactions
Esmolol + Propofol
Severity: Moderate
Esmolol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and esmolol reduces heart rate and contractility. Together they can cause marked hypotension and bradycardia during anesthesia.
What this interaction means in plain words
Esmolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic cardiovascular depression from propofol vasodilation and negative inotropy plus beta-1 blockade.
What to do
Titrate both agents to effect with continuous hemodynamic monitoring. Have vasopressors and anticholinergics available and reduce doses in elderly or hypovolemic patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Propofol
Frequently asked questions
Can I take Esmolol with Propofol?
MediHelp rates the interaction as moderate. Esmolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and esmolol reduces heart rate and contractility. Together they can cause marked hypotension and bradycardia during anesthesia.
How serious is the interaction between Esmolol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both agents to effect with continuous hemodynamic monitoring. Have vasopressors and anticholinergics available and reduce doses in elderly or hypovolemic patients.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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