Drug interactions
Esomeprazole + Fluconazole
Severity: Minor
Esomeprazole and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19 and CYP3A4 and can increase esomeprazole exposure. Standard doses are usually well tolerated, so the effect is rarely harmful.
What this interaction means in plain words
Esomeprazole and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP2C19 and CYP3A4, reducing esomeprazole metabolism.
What to do
No routine dose change is needed. Consider a dose reduction only if high-dose, long-term esomeprazole is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Esomeprazole with Fluconazole?
MediHelp rates the interaction as minor. Esomeprazole and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole inhibits CYP2C19 and CYP3A4 and can increase esomeprazole exposure. Standard doses are usually well tolerated, so the effect is rarely harmful.
How serious is the interaction between Esomeprazole and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Consider a dose reduction only if high-dose, long-term esomeprazole is used.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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