Drug interactions
Estradiol + Fluconazole
Severity: Minor
Estradiol and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol is metabolized partly by CYP3A4, and fluconazole may raise its levels. Higher estrogen exposure may increase estrogenic effects such as breast tenderness, fluid retention and nausea.
What this interaction means in plain words
Estradiol and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4-mediated estradiol metabolism.
What to do
No routine adjustment is needed; watch for estrogenic adverse effects and reduce the estradiol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Fluconazole?
MediHelp rates the interaction as minor. Estradiol and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estradiol is metabolized partly by CYP3A4, and fluconazole may raise its levels. Higher estrogen exposure may increase estrogenic effects such as breast tenderness, fluid retention and nausea.
How serious is the interaction between Estradiol and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for estrogenic adverse effects and reduce the estradiol dose if they occur.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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