Drug interactions
Estradiol + Idelalisib
Severity: Moderate
Estradiol and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can increase estradiol exposure. Higher estrogen levels may increase adverse effects such as breast tenderness, bleeding and thrombotic risk.
What this interaction means in plain words
Estradiol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Idelalisib belongs to Oncology.
Why it happens
Idelalisib strongly inhibits CYP3A4, reducing estradiol metabolism.
What to do
Monitor for estrogen excess and reduce the estradiol dose if symptoms occur. Reassess the need for estrogen therapy in patients with thrombotic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Estradiol with Idelalisib?
MediHelp rates the interaction as moderate. Estradiol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and can increase estradiol exposure. Higher estrogen levels may increase adverse effects such as breast tenderness, bleeding and thrombotic risk.
How serious is the interaction between Estradiol and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess and reduce the estradiol dose if symptoms occur. Reassess the need for estrogen therapy in patients with thrombotic risk factors.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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