Drug interactions
Estradiol + Levoketoconazole
Severity: Moderate
Estradiol and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and P-glycoprotein inhibitor, so estradiol exposure can increase. This may cause estrogenic adverse effects and increase thrombotic risk.
What this interaction means in plain words
Estradiol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 and P-glycoprotein inhibition decreases estradiol clearance and increases absorption.
What to do
Monitor for estrogen excess and reduce the estradiol dose if adverse effects occur. Consider a transdermal route to bypass first-pass metabolism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Estradiol with Levoketoconazole?
MediHelp rates the interaction as moderate. Estradiol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and P-glycoprotein inhibitor, so estradiol exposure can increase. This may cause estrogenic adverse effects and increase thrombotic risk.
How serious is the interaction between Estradiol and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess and reduce the estradiol dose if adverse effects occur. Consider a transdermal route to bypass first-pass metabolism.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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