Drug interactions
Estradiol + Lopinavir
Severity: Moderate
Estradiol and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 but may also induce other metabolic pathways, so the net effect on estradiol is unpredictable. Estrogenic effects or reduced efficacy may both occur.
What this interaction means in plain words
Estradiol and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition may raise estradiol, while ritonavir-related induction of glucuronidation may lower it.
What to do
Monitor symptom control and estrogenic adverse effects and titrate the estradiol dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Estradiol with Lopinavir?
MediHelp rates the interaction as moderate. Estradiol and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir inhibits CYP3A4 but may also induce other metabolic pathways, so the net effect on estradiol is unpredictable. Estrogenic effects or reduced efficacy may both occur.
How serious is the interaction between Estradiol and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and estrogenic adverse effects and titrate the estradiol dose accordingly.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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