Drug interactions
Estradiol + Nevirapine
Severity: Moderate
Estradiol and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower estrogen exposure, reducing the efficacy of hormone therapy or hormonal contraception and potentially causing breakthrough bleeding or loss of symptom control.
What this interaction means in plain words
Estradiol and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing hepatic metabolism of estradiol.
What to do
Monitor symptom control and bleeding patterns and adjust the estrogen dose as needed. For contraception, use an additional or alternative non-hormonal method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Nevirapine?
MediHelp rates the interaction as moderate. Estradiol and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can lower estrogen exposure, reducing the efficacy of hormone therapy or hormonal contraception and potentially causing breakthrough bleeding or loss of symptom control.
How serious is the interaction between Estradiol and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and bleeding patterns and adjust the estrogen dose as needed. For contraception, use an additional or alternative non-hormonal method.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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