Drug interactions
Etanercept + Everolimus
Severity: Moderate
Etanercept and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined TNF blockade and mTOR inhibition increases overall immunosuppression and the risk of serious infections. Everolimus also carries its own infection risk in transplant and oncology settings.
What this interaction means in plain words
Etanercept and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etanercept belongs to Musculoskeletal; Everolimus belongs to Oncology.
Why it happens
Additive immunosuppression via TNF blockade and mTOR inhibition.
What to do
Monitor for signs of infection and screen for latent infections before combined use; reassess the need for both agents regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Everolimus?
MediHelp rates the interaction as moderate. Etanercept and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined TNF blockade and mTOR inhibition increases overall immunosuppression and the risk of serious infections. Everolimus also carries its own infection risk in transplant and oncology settings.
How serious is the interaction between Etanercept and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and screen for latent infections before combined use; reassess the need for both agents regularly.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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