Drug interactions
Etanercept + Hydroxychloroquine
Severity: Minor
Etanercept and Hydroxychloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine is commonly combined with TNF inhibitors such as etanercept in rheumatoid arthritis, and it has no meaningful immunosuppressive effect that would add materially to infection risk. There is no established interaction beyond the infection risk of etanercept itself.
What this interaction means in plain words
Etanercept and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etanercept belongs to Musculoskeletal; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
No established pharmacokinetic or pharmacodynamic interaction; hydroxychloroquine is only weakly immunomodulatory.
What to do
No change in therapy is needed. Continue routine infection monitoring for etanercept.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Hydroxychloroquine?
MediHelp rates the interaction as minor. Etanercept and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxychloroquine is commonly combined with TNF inhibitors such as etanercept in rheumatoid arthritis, and it has no meaningful immunosuppressive effect that would add materially to infection risk. There is no established interaction beyond the infection risk of etanercept itself.
How serious is the interaction between Etanercept and Hydroxychloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in therapy is needed. Continue routine infection monitoring for etanercept.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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