Drug interactions
Ethacrynic acid + Magnesium sulphate
Severity: Minor
Ethacrynic acid and Magnesium sulphate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid increase urinary magnesium excretion and can lead to hypomagnesemia, particularly with prolonged use. Low magnesium may worsen hypokalemia and raise arrhythmia risk.
What this interaction means in plain words
Ethacrynic acid and Magnesium sulphate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethacrynic acid belongs to Cardiovascular; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Inhibition of tubular reabsorption in the loop of Henle increases renal magnesium loss.
What to do
Monitor serum magnesium and potassium during prolonged diuretic therapy and replace magnesium when low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Magnesium sulphate?
MediHelp rates the interaction as minor. Ethacrynic acid and Magnesium sulphate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loop diuretics such as ethacrynic acid increase urinary magnesium excretion and can lead to hypomagnesemia, particularly with prolonged use. Low magnesium may worsen hypokalemia and raise arrhythmia risk.
How serious is the interaction between Ethacrynic acid and Magnesium sulphate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium during prolonged diuretic therapy and replace magnesium when low.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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