Drug interactions
Ethinyl estradiol-drospirenone + Momelotinib
Severity: Minor
Ethinyl estradiol-drospirenone and Momelotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP and may increase exposure to BCRP substrates, and ethinyl estradiol is a substrate of intestinal efflux transporters. Exposure to the estrogen may rise modestly, which could slightly increase estrogenic adverse effects. The clinical importance is uncertain.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Momelotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Momelotinib belongs to Oncology.
Why it happens
Inhibition of BCRP efflux transport by momelotinib may increase ethinyl estradiol absorption and exposure.
What to do
No empirical dose change is needed. Monitor for estrogenic effects such as breast tenderness, nausea or blood pressure rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Momelotinib?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Momelotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Momelotinib inhibits BCRP and may increase exposure to BCRP substrates, and ethinyl estradiol is a substrate of intestinal efflux transporters. Exposure to the estrogen may rise modestly, which could slightly increase estrogenic adverse effects. The clinical importance is uncertain.
How serious is the interaction between Ethinyl estradiol-drospirenone and Momelotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for estrogenic effects such as breast tenderness, nausea or blood pressure rise.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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