Drug interactions
Ethinyl estradiol-drospirenone + Perampanel
Severity: Moderate
Ethinyl estradiol-drospirenone and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel at higher doses can lower levonorgestrel exposure and may reduce the efficacy of hormonal contraceptives, and similar effects are possible with other progestins. Contraceptive failure or breakthrough bleeding could result.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Perampanel belongs to Central Nervous System.
Why it happens
Perampanel is a weak CYP3A inducer at higher doses, which may increase metabolism of contraceptive steroids.
What to do
Counsel patients to use an additional non-hormonal contraceptive method when perampanel dose is 12 mg daily or more and for about one month after stopping it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Perampanel?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel at higher doses can lower levonorgestrel exposure and may reduce the efficacy of hormonal contraceptives, and similar effects are possible with other progestins. Contraceptive failure or breakthrough bleeding could result.
How serious is the interaction between Ethinyl estradiol-drospirenone and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to use an additional non-hormonal contraceptive method when perampanel dose is 12 mg daily or more and for about one month after stopping it.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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