Drug interactions
Ethinyl estradiol-drospirenone + Posaconazole
Severity: Moderate
Ethinyl estradiol-drospirenone and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and may raise ethinyl estradiol and drospirenone exposure. This could increase estrogenic adverse effects such as nausea, breast tenderness and thrombotic risk, though the effect is typically modest.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by posaconazole decreases metabolism of ethinyl estradiol.
What to do
Monitor for estrogen-related adverse effects and blood pressure during antifungal therapy, and consider an alternative contraceptive for prolonged courses; check potassium given drospirenone exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Posaconazole?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and may raise ethinyl estradiol and drospirenone exposure. This could increase estrogenic adverse effects such as nausea, breast tenderness and thrombotic risk, though the effect is typically modest.
How serious is the interaction between Ethinyl estradiol-drospirenone and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects and blood pressure during antifungal therapy, and consider an alternative contraceptive for prolonged courses; check potassium given drospirenone exposure.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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