Drug interactions
Ethinyl estradiol-drospirenone + Teriflunomide
Severity: Moderate
Ethinyl estradiol-drospirenone and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide can raise ethinyl estradiol exposure moderately, increasing estrogenic adverse effects. Teriflunomide is also teratogenic, so reliable contraception is essential.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Probable inhibition of BCRP or CYP-mediated ethinyl estradiol clearance by teriflunomide; exact mechanism not fully established.
What to do
Choose a contraceptive with the lowest suitable estrogen dose and monitor for estrogenic adverse effects and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Teriflunomide?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide can raise ethinyl estradiol exposure moderately, increasing estrogenic adverse effects. Teriflunomide is also teratogenic, so reliable contraception is essential.
How serious is the interaction between Ethinyl estradiol-drospirenone and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a contraceptive with the lowest suitable estrogen dose and monitor for estrogenic adverse effects and blood pressure.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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