Drug interactions
Ethinyl estradiol-drospirenone + Tigecycline
Severity: Minor
Ethinyl estradiol-drospirenone and Tigecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Broad-spectrum antibiotics have been theorised to reduce enterohepatic recirculation of ethinyl estradiol and so lower its levels. Controlled data show no consistent loss of contraceptive efficacy, so the clinical risk is considered low.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Tigecycline belongs to Anti Bacterial.
Why it happens
Possible reduction of gut flora that deconjugate estrogen metabolites, lowering enterohepatic recycling; not well established.
What to do
No routine change is needed; counsel the patient to use backup contraception if vomiting or severe diarrhea occurs while on the antibiotic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Tigecycline
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Tigecycline?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Broad-spectrum antibiotics have been theorised to reduce enterohepatic recirculation of ethinyl estradiol and so lower its levels. Controlled data show no consistent loss of contraceptive efficacy, so the clinical risk is considered low.
How serious is the interaction between Ethinyl estradiol-drospirenone and Tigecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to use backup contraception if vomiting or severe diarrhea occurs while on the antibiotic.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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