Drug interactions
Etomidate + Metoclopramide
Severity: Moderate
Etomidate and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is a short-acting anesthetic induction agent, and metoclopramide may add to sedation or reduce the anesthetic dose needed. Both are commonly used in the perioperative setting, where the combined effect is anticipated and manageable.
What this interaction means in plain words
Etomidate and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depressant effects.
What to do
Titrate the etomidate dose to effect and monitor sedation and hemodynamics during induction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Metoclopramide?
MediHelp rates the interaction as moderate. Etomidate and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is a short-acting anesthetic induction agent, and metoclopramide may add to sedation or reduce the anesthetic dose needed. Both are commonly used in the perioperative setting, where the combined effect is anticipated and manageable.
How serious is the interaction between Etomidate and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the etomidate dose to effect and monitor sedation and hemodynamics during induction.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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