Drug interactions
Etomidate + Propofol
Severity: Moderate
Etomidate and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are intravenous hypnotics, and giving them together produces additive sedation and may deepen anesthesia. They are sometimes co-administered deliberately to lessen etomidate-induced myoclonus or propofol hypotension.
What this interaction means in plain words
Etomidate and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor-mediated CNS depression.
What to do
Reduce the dose of each agent when combined and monitor blood pressure, ventilation and depth of anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Propofol?
MediHelp rates the interaction as moderate. Etomidate and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are intravenous hypnotics, and giving them together produces additive sedation and may deepen anesthesia. They are sometimes co-administered deliberately to lessen etomidate-induced myoclonus or propofol hypotension.
How serious is the interaction between Etomidate and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dose of each agent when combined and monitor blood pressure, ventilation and depth of anesthesia.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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