Drug interactions
Etonogestrel + Posaconazole
Severity: Minor
Etonogestrel and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etonogestrel is metabolized by CYP3A4, so posaconazole may raise progestin concentrations. This is unlikely to reduce contraceptive efficacy but may increase progestogenic adverse effects.
What this interaction means in plain words
Etonogestrel and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of etonogestrel.
What to do
No dose change is generally required; counsel the patient to report progestogenic adverse effects or bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Posaconazole?
MediHelp rates the interaction as minor. Etonogestrel and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etonogestrel is metabolized by CYP3A4, so posaconazole may raise progestin concentrations. This is unlikely to reduce contraceptive efficacy but may increase progestogenic adverse effects.
How serious is the interaction between Etonogestrel and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; counsel the patient to report progestogenic adverse effects or bleeding changes.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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