Drug interactions
Etravirine + Medroxyprogesterone
Severity: Moderate
Etravirine and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower progestin concentrations, raising the possibility of contraceptive failure. Injectable depot medroxyprogesterone appears less affected, but oral forms may be reduced.
What this interaction means in plain words
Etravirine and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Medroxyprogesterone belongs to Endocrine.
Why it happens
Etravirine induces CYP3A4, increasing medroxyprogesterone metabolism.
What to do
Counsel on additional barrier contraception while on etravirine and monitor for breakthrough bleeding or reduced efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Etravirine and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower progestin concentrations, raising the possibility of contraceptive failure. Injectable depot medroxyprogesterone appears less affected, but oral forms may be reduced.
How serious is the interaction between Etravirine and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additional barrier contraception while on etravirine and monitor for breakthrough bleeding or reduced efficacy.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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