Drug interactions
Etravirine + Posaconazole
Severity: Moderate
Etravirine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 substrate and an inducer of CYP3A4, and posaconazole may raise etravirine exposure. Etravirine may also lower posaconazole concentrations through induction of its metabolism, which could reduce antifungal efficacy.
What this interaction means in plain words
Etravirine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of etravirine, while etravirine induces CYP3A4 and UGT pathways that clear posaconazole.
What to do
Monitor for etravirine adverse effects such as rash. Check posaconazole trough concentrations in patients on prolonged therapy and adjust the dose to maintain target levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Posaconazole?
MediHelp rates the interaction as moderate. Etravirine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 substrate and an inducer of CYP3A4, and posaconazole may raise etravirine exposure. Etravirine may also lower posaconazole concentrations through induction of its metabolism, which could reduce antifungal efficacy.
How serious is the interaction between Etravirine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for etravirine adverse effects such as rash. Check posaconazole trough concentrations in patients on prolonged therapy and adjust the dose to maintain target levels.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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