Drug interactions
Etravirine + Progesterone
Severity: Moderate
Etravirine and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower progesterone concentrations. This could reduce efficacy for endometrial protection or luteal support.
What this interaction means in plain words
Etravirine and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Progesterone belongs to Endocrine.
Why it happens
Etravirine induces CYP3A4, increasing progesterone clearance.
What to do
Monitor for loss of progesterone effect, such as breakthrough bleeding, and increase the dose or choose an alternative if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Progesterone?
MediHelp rates the interaction as moderate. Etravirine and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower progesterone concentrations. This could reduce efficacy for endometrial protection or luteal support.
How serious is the interaction between Etravirine and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of progesterone effect, such as breakthrough bleeding, and increase the dose or choose an alternative if needed.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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