Drug interactions
Etravirine + Ticlopidine
Severity: Moderate
Etravirine and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19, which metabolizes etravirine, and may increase etravirine concentrations. Etravirine as an inducer of CYP3A4 may also lower ticlopidine exposure, though ticlopidine is not mainly CYP3A4 dependent.
What this interaction means in plain words
Etravirine and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2C19 reducing etravirine clearance; etravirine induces CYP enzymes that may increase ticlopidine metabolism.
What to do
Monitor for etravirine adverse effects such as rash and for ticlopidine efficacy and hematologic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etravirine and Ticlopidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ticlopidine
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ticlopidine?
MediHelp rates the interaction as moderate. Etravirine and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C19, which metabolizes etravirine, and may increase etravirine concentrations. Etravirine as an inducer of CYP3A4 may also lower ticlopidine exposure, though ticlopidine is not mainly CYP3A4 dependent.
How serious is the interaction between Etravirine and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for etravirine adverse effects such as rash and for ticlopidine efficacy and hematologic parameters.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
