Drug interactions
Everolimus + Palbociclib
Severity: Moderate
Everolimus and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak time-dependent inhibitor of CYP3A4 and may modestly raise exposure to everolimus, a sensitive CYP3A4 and P-gp substrate. Higher everolimus levels could increase stomatitis, myelosuppression, infections and pneumonitis.
What this interaction means in plain words
Everolimus and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Palbociclib inhibits intestinal and hepatic CYP3A4, reducing the metabolic clearance of everolimus.
What to do
Monitor everolimus trough concentrations where available and watch for mucositis, cytopenias and pneumonitis. Reduce the everolimus dose or interrupt treatment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Everolimus with Palbociclib?
MediHelp rates the interaction as moderate. Everolimus and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak time-dependent inhibitor of CYP3A4 and may modestly raise exposure to everolimus, a sensitive CYP3A4 and P-gp substrate. Higher everolimus levels could increase stomatitis, myelosuppression, infections and pneumonitis.
How serious is the interaction between Everolimus and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations where available and watch for mucositis, cytopenias and pneumonitis. Reduce the everolimus dose or interrupt treatment if toxicity develops.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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