Drug interactions
Everolimus + Pregabalin
Severity: Moderate
Everolimus and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both pregabalin and mTOR inhibitors such as everolimus can cause angioedema, so using them together may raise the chance of swelling of the face, lips, tongue and airway. Airway involvement can be life-threatening.
What this interaction means in plain words
Everolimus and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Pregabalin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic risk of angioedema; each drug is independently associated with this reaction.
What to do
Counsel the patient to stop the drugs and seek urgent care for any swelling of the face, mouth or throat. Monitor closely when starting the combination, especially if the patient has had angioedema before.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Pregabalin?
MediHelp rates the interaction as moderate. Everolimus and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both pregabalin and mTOR inhibitors such as everolimus can cause angioedema, so using them together may raise the chance of swelling of the face, lips, tongue and airway. Airway involvement can be life-threatening.
How serious is the interaction between Everolimus and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to stop the drugs and seek urgent care for any swelling of the face, mouth or throat. Monitor closely when starting the combination, especially if the patient has had angioedema before.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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