Drug interactions
Everolimus + Stiripentol
Severity: Moderate
Everolimus and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so everolimus exposure may change unpredictably. Levels may rise, causing toxicity, or fall, causing loss of effect. This is relevant in tuberous sclerosis patients with seizures.
What this interaction means in plain words
Everolimus and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-gp inhibition by stiripentol alters everolimus clearance and absorption.
What to do
Monitor everolimus trough concentrations after starting, changing or stopping stiripentol. Adjust the everolimus dose to the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Everolimus with Stiripentol?
MediHelp rates the interaction as moderate. Everolimus and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so everolimus exposure may change unpredictably. Levels may rise, causing toxicity, or fall, causing loss of effect. This is relevant in tuberous sclerosis patients with seizures.
How serious is the interaction between Everolimus and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations after starting, changing or stopping stiripentol. Adjust the everolimus dose to the target range.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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