Drug interactions
Ezetimibe + Fostemsavir
Severity: Minor
Ezetimibe and Fostemsavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's metabolite inhibits OATP1B1/1B3, which may increase ezetimibe exposure. Clinical impact is probably small.
What this interaction means in plain words
Ezetimibe and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ezetimibe belongs to Cardiovascular; Fostemsavir belongs to Anti Virals.
Why it happens
OATP1B1/1B3 inhibition reduces hepatic uptake of ezetimibe.
What to do
No routine adjustment is needed; monitor for ezetimibe adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Ezetimibe with Fostemsavir?
MediHelp rates the interaction as minor. Ezetimibe and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's metabolite inhibits OATP1B1/1B3, which may increase ezetimibe exposure. Clinical impact is probably small.
How serious is the interaction between Ezetimibe and Fostemsavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for ezetimibe adverse effects.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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