Drug interactions
Ezetimibe + Leniolisib
Severity: Minor
Ezetimibe and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1/1B3 and may raise ezetimibe exposure. Ezetimibe has a wide safety margin, so clinical consequences are probably modest.
What this interaction means in plain words
Ezetimibe and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ezetimibe belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of ezetimibe.
What to do
No dose change is needed. Monitor for adverse effects such as gastrointestinal upset or liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Other interactions of Leniolisib
Frequently asked questions
Can I take Ezetimibe with Leniolisib?
MediHelp rates the interaction as minor. Ezetimibe and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits OATP1B1/1B3 and may raise ezetimibe exposure. Ezetimibe has a wide safety margin, so clinical consequences are probably modest.
How serious is the interaction between Ezetimibe and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for adverse effects such as gastrointestinal upset or liver enzyme elevation.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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