Drug interactions
Fedratinib + Ixazomib
Severity: Minor
Fedratinib and Ixazomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise ixazomib concentrations. Ixazomib clearance involves several CYPs, so the effect is probably limited.
What this interaction means in plain words
Fedratinib and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Ixazomib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, which may modestly reduce ixazomib metabolism.
What to do
No dose change is required by labeling for moderate inhibitors; monitor for ixazomib toxicity such as thrombocytopenia and gastrointestinal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Ixazomib?
MediHelp rates the interaction as minor. Fedratinib and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is a moderate CYP3A4 inhibitor and may raise ixazomib concentrations. Ixazomib clearance involves several CYPs, so the effect is probably limited.
How serious is the interaction between Fedratinib and Ixazomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required by labeling for moderate inhibitors; monitor for ixazomib toxicity such as thrombocytopenia and gastrointestinal effects.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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