Drug interactions
Fedratinib + Lacosamide
Severity: Minor
Fedratinib and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and other enzymes and may increase lacosamide concentrations. Because lacosamide is cleared by several pathways, the increase is probably modest but may heighten dizziness and PR-interval effects.
What this interaction means in plain words
Fedratinib and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Lacosamide belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 (and CYP2C19) by fedratinib reduces lacosamide metabolism.
What to do
Monitor for dizziness, ataxia and bradycardia, and lower the lacosamide dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Lacosamide?
MediHelp rates the interaction as minor. Fedratinib and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib inhibits CYP3A4 and other enzymes and may increase lacosamide concentrations. Because lacosamide is cleared by several pathways, the increase is probably modest but may heighten dizziness and PR-interval effects.
How serious is the interaction between Fedratinib and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, ataxia and bradycardia, and lower the lacosamide dose if adverse effects occur.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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