Drug interactions
Fedratinib + Methamphetamine
Severity: Moderate
Fedratinib and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP2D6 inhibitor, and methamphetamine is partly metabolized by CYP2D6. Exposure to methamphetamine may rise, increasing sympathomimetic effects such as hypertension, tachycardia and agitation.
What this interaction means in plain words
Fedratinib and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Methamphetamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of methamphetamine by fedratinib.
What to do
Monitor heart rate, blood pressure and signs of excess stimulation, and lower the methamphetamine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Methamphetamine?
MediHelp rates the interaction as moderate. Fedratinib and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP2D6 inhibitor, and methamphetamine is partly metabolized by CYP2D6. Exposure to methamphetamine may rise, increasing sympathomimetic effects such as hypertension, tachycardia and agitation.
How serious is the interaction between Fedratinib and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and signs of excess stimulation, and lower the methamphetamine dose if these occur.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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