Drug interactions
Fedratinib + Mirtazapine
Severity: Moderate
Fedratinib and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, both of which contribute to mirtazapine metabolism. Mirtazapine exposure may rise, increasing sedation, weight gain effects and other dose-related adverse effects.
What this interaction means in plain words
Fedratinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 and CYP2D6 by fedratinib reduces mirtazapine clearance.
What to do
Monitor for excess sedation, dizziness and other adverse effects, and reduce the mirtazapine dose if they occur. Reassess the dose when fedratinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Mirtazapine?
MediHelp rates the interaction as moderate. Fedratinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, both of which contribute to mirtazapine metabolism. Mirtazapine exposure may rise, increasing sedation, weight gain effects and other dose-related adverse effects.
How serious is the interaction between Fedratinib and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and other adverse effects, and reduce the mirtazapine dose if they occur. Reassess the dose when fedratinib is stopped.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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