Drug interactions
Fedratinib + Modafinil
Severity: Moderate
Fedratinib and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolised by CYP3A4 and CYP2C19. Modafinil inhibits CYP2C19 but weakly induces CYP3A4, so net effect on fedratinib exposure is uncertain and has not been studied. Higher exposure could increase toxicities such as GI effects, cytopenias and encephalopathy risk.
What this interaction means in plain words
Fedratinib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil inhibits CYP2C19 and weakly induces CYP3A4, so its net effect on fedratinib metabolism is uncertain.
What to do
Monitor blood counts and tolerability of fedratinib, and reduce its dose if toxicity occurs. Consider an alternative to modafinil if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Modafinil?
MediHelp rates the interaction as moderate. Fedratinib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is metabolised by CYP3A4 and CYP2C19. Modafinil inhibits CYP2C19 but weakly induces CYP3A4, so net effect on fedratinib exposure is uncertain and has not been studied. Higher exposure could increase toxicities such as GI effects, cytopenias and encephalopathy risk.
How serious is the interaction between Fedratinib and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tolerability of fedratinib, and reduce its dose if toxicity occurs. Consider an alternative to modafinil if feasible.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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