Drug interactions
Fedratinib + Nevirapine
Severity: Moderate
Fedratinib and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is a CYP3A4 inducer and moderate inhibitory/inducing effects complicate this pairing. Fedratinib exposure may fall, reducing efficacy in myelofibrosis, while fedratinib may modestly alter nevirapine levels.
What this interaction means in plain words
Fedratinib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, which metabolizes fedratinib; fedratinib is itself a moderate CYP3A4 inhibitor.
What to do
Monitor spleen response and hematologic parameters, and monitor nevirapine tolerability including liver tests and rash.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Nevirapine?
MediHelp rates the interaction as moderate. Fedratinib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is a CYP3A4 inducer and moderate inhibitory/inducing effects complicate this pairing. Fedratinib exposure may fall, reducing efficacy in myelofibrosis, while fedratinib may modestly alter nevirapine levels.
How serious is the interaction between Fedratinib and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen response and hematologic parameters, and monitor nevirapine tolerability including liver tests and rash.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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