Drug interactions
Fedratinib + Ondansetron
Severity: Moderate
Fedratinib and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and other enzymes and may increase ondansetron exposure. Because ondansetron is metabolized by several enzymes, the increase is probably modest, but higher levels add to QT risk.
What this interaction means in plain words
Fedratinib and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition by fedratinib decreases ondansetron clearance.
What to do
Use the lowest effective ondansetron dose and avoid repeated high doses. Check electrolytes and consider an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Ondansetron?
MediHelp rates the interaction as moderate. Fedratinib and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and other enzymes and may increase ondansetron exposure. Because ondansetron is metabolized by several enzymes, the increase is probably modest, but higher levels add to QT risk.
How serious is the interaction between Fedratinib and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ondansetron dose and avoid repeated high doses. Check electrolytes and consider an ECG in patients with cardiac risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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