Drug interactions
Fedratinib + Palbociclib
Severity: Moderate
Fedratinib and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase palbociclib exposure. This could intensify neutropenia and other adverse effects of palbociclib.
What this interaction means in plain words
Fedratinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing palbociclib metabolic clearance; both drugs also cause myelosuppression.
What to do
Monitor complete blood counts regularly and reduce the palbociclib dose if neutropenia or other toxicity occurs. Fedratinib is itself a CYP3A4 substrate, so watch for overall toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Palbociclib?
MediHelp rates the interaction as moderate. Fedratinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase palbociclib exposure. This could intensify neutropenia and other adverse effects of palbociclib.
How serious is the interaction between Fedratinib and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce the palbociclib dose if neutropenia or other toxicity occurs. Fedratinib is itself a CYP3A4 substrate, so watch for overall toxicity.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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