Drug interactions
Fedratinib + Ranolazine
Severity: Moderate
Fedratinib and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise ranolazine concentrations. Higher ranolazine exposure increases dose-related QT prolongation, dizziness and nausea.
What this interaction means in plain words
Fedratinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Fedratinib inhibits CYP3A4-mediated metabolism of ranolazine.
What to do
Limit ranolazine to 500 mg twice daily with moderate CYP3A inhibitors and monitor tolerability and QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Ranolazine?
MediHelp rates the interaction as moderate. Fedratinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can raise ranolazine concentrations. Higher ranolazine exposure increases dose-related QT prolongation, dizziness and nausea.
How serious is the interaction between Fedratinib and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ranolazine to 500 mg twice daily with moderate CYP3A inhibitors and monitor tolerability and QTc.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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