Drug interactions
Felbamate + Mifepristone
Severity: Moderate
Felbamate and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is partly metabolized by CYP3A4, so mifepristone may modestly raise its levels. Felbamate also induces CYP3A4, which could lower mifepristone concentrations and complicate the net effect. The clinical significance is uncertain.
What this interaction means in plain words
Felbamate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 while felbamate is a weak CYP3A4 inducer, giving opposing, poorly characterized effects.
What to do
Monitor for felbamate toxicity such as nausea, insomnia and hematologic effects, and for reduced mifepristone effect. Adjust doses according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Felbamate and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Mifepristone?
MediHelp rates the interaction as moderate. Felbamate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate is partly metabolized by CYP3A4, so mifepristone may modestly raise its levels. Felbamate also induces CYP3A4, which could lower mifepristone concentrations and complicate the net effect. The clinical significance is uncertain.
How serious is the interaction between Felbamate and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for felbamate toxicity such as nausea, insomnia and hematologic effects, and for reduced mifepristone effect. Adjust doses according to response.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
