Drug interactions
Felbamate + Secobarbital
Severity: Moderate
Felbamate and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce felbamate concentrations, and the two drugs have additive sedative effects. Felbamate can also raise barbiturate levels, complicating the net effect.
What this interaction means in plain words
Felbamate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate CYP3A4 induction increases felbamate clearance, while felbamate inhibits CYP2C19 and adds CNS depression.
What to do
Monitor seizure control, sedation and felbamate response. Adjust doses of either drug based on clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Secobarbital?
MediHelp rates the interaction as moderate. Felbamate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may reduce felbamate concentrations, and the two drugs have additive sedative effects. Felbamate can also raise barbiturate levels, complicating the net effect.
How serious is the interaction between Felbamate and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control, sedation and felbamate response. Adjust doses of either drug based on clinical effect.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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