Drug interactions
Felbamate + Valproic acid
Severity: Moderate
Felbamate and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate can raise felbamate concentrations, and felbamate may in turn raise valproate levels. Combined use can increase adverse effects such as sedation, nausea and dizziness, and both drugs carry hepatic risk.
What this interaction means in plain words
Felbamate and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
Mutual inhibition of hepatic metabolism of the two drugs.
What to do
Monitor serum concentrations, liver function and blood counts, and reduce the dose of either drug if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Valproic acid?
MediHelp rates the interaction as moderate. Felbamate and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valproate can raise felbamate concentrations, and felbamate may in turn raise valproate levels. Combined use can increase adverse effects such as sedation, nausea and dizziness, and both drugs carry hepatic risk.
How serious is the interaction between Felbamate and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum concentrations, liver function and blood counts, and reduce the dose of either drug if toxicity appears.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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