Drug interactions
Felodipine + Silodosin
Severity: Minor
Felodipine and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine and silodosin both lower blood pressure, so additive hypotension can occur. Felodipine may also inhibit P-glycoprotein, possibly raising silodosin levels slightly.
What this interaction means in plain words
Felodipine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade and calcium channel blockade, plus possible P-glycoprotein inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting either drug. Advise slow position changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Silodosin?
MediHelp rates the interaction as minor. Felodipine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine and silodosin both lower blood pressure, so additive hypotension can occur. Felodipine may also inhibit P-glycoprotein, possibly raising silodosin levels slightly.
How serious is the interaction between Felodipine and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting either drug. Advise slow position changes.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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