Drug interactions
Fenfluramine + Melatonin
Severity: Minor
Fenfluramine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine commonly causes somnolence and fatigue in treated patients, and melatonin is also sedating. The net effect is uncertain but additive drowsiness is plausible.
What this interaction means in plain words
Fenfluramine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenfluramine belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Possible additive sedation; no established pharmacokinetic or pharmacodynamic interaction.
What to do
Monitor for excessive daytime sleepiness when melatonin is added to fenfluramine. Reduce or stop melatonin if somnolence worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Melatonin?
MediHelp rates the interaction as minor. Fenfluramine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine commonly causes somnolence and fatigue in treated patients, and melatonin is also sedating. The net effect is uncertain but additive drowsiness is plausible.
How serious is the interaction between Fenfluramine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive daytime sleepiness when melatonin is added to fenfluramine. Reduce or stop melatonin if somnolence worsens.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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