Drug interactions
Fenfluramine + Methamphetamine
Severity: Moderate
Fenfluramine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on monoamine systems and can raise heart rate and blood pressure, and fenfluramine also carries a risk of valvular heart disease and pulmonary hypertension. Combined use may heighten cardiovascular strain and serotonergic or stimulant effects such as agitation and insomnia.
What this interaction means in plain words
Fenfluramine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic and serotonergic/monoaminergic effects.
What to do
Monitor blood pressure, heart rate and mental status. Follow the scheduled echocardiographic monitoring required for fenfluramine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Methamphetamine?
MediHelp rates the interaction as moderate. Fenfluramine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on monoamine systems and can raise heart rate and blood pressure, and fenfluramine also carries a risk of valvular heart disease and pulmonary hypertension. Combined use may heighten cardiovascular strain and serotonergic or stimulant effects such as agitation and insomnia.
How serious is the interaction between Fenfluramine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mental status. Follow the scheduled echocardiographic monitoring required for fenfluramine.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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