Drug interactions
Fenfluramine + Midodrine
Severity: Moderate
Fenfluramine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine has serotonergic and sympathomimetic activity, and combined use with midodrine may add to blood pressure elevation. The clinical significance is not well characterized, but supine hypertension is a concern with midodrine.
What this interaction means in plain words
Fenfluramine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Possible additive pressor effect from adrenergic stimulation; the interaction is largely predicted rather than established.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Reduce midodrine dose if supine hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Midodrine?
MediHelp rates the interaction as moderate. Fenfluramine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine has serotonergic and sympathomimetic activity, and combined use with midodrine may add to blood pressure elevation. The clinical significance is not well characterized, but supine hypertension is a concern with midodrine.
How serious is the interaction between Fenfluramine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Reduce midodrine dose if supine hypertension develops.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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