Drug interactions
Fenfluramine + Modafinil
Severity: Moderate
Fenfluramine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause central stimulation or reduced sleepiness, and fenfluramine may also cause insomnia, decreased appetite and agitation. Combined use may add to insomnia, anxiety and cardiovascular stimulation.
What this interaction means in plain words
Fenfluramine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Additive CNS stimulant pharmacodynamic effects; no established pharmacokinetic interaction.
What to do
Monitor for insomnia, agitation, heart rate and blood pressure changes, and review the modafinil dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Modafinil?
MediHelp rates the interaction as moderate. Fenfluramine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause central stimulation or reduced sleepiness, and fenfluramine may also cause insomnia, decreased appetite and agitation. Combined use may add to insomnia, anxiety and cardiovascular stimulation.
How serious is the interaction between Fenfluramine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for insomnia, agitation, heart rate and blood pressure changes, and review the modafinil dose if these occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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