Drug interactions
Fenfluramine + Rizatriptan
Severity: Moderate
Fenfluramine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases extracellular serotonin and its labeling warns of serotonin syndrome with other serotonergic agents. Triptans add to this risk. Symptoms include mental status changes, autonomic instability and neuromuscular hyperactivity.
What this interaction means in plain words
Fenfluramine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from serotonin release by fenfluramine and 5-HT1B/1D receptor agonism by rizatriptan.
What to do
Monitor for serotonin syndrome, particularly at initiation and dose changes. Discontinue one or both drugs if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Rizatriptan?
MediHelp rates the interaction as moderate. Fenfluramine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine increases extracellular serotonin and its labeling warns of serotonin syndrome with other serotonergic agents. Triptans add to this risk. Symptoms include mental status changes, autonomic instability and neuromuscular hyperactivity.
How serious is the interaction between Fenfluramine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, particularly at initiation and dose changes. Discontinue one or both drugs if it develops.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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