Drug interactions
Fenfluramine + Sevoflurane
Severity: Moderate
Fenfluramine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine has serotonergic and sympathomimetic activity and can raise blood pressure. With volatile anesthetics, hemodynamic instability or arrhythmia is theoretically possible, though clinical data are limited.
What this interaction means in plain words
Fenfluramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Mechanism is not firmly established; additive sympathomimetic and cardiovascular effects with myocardial sensitization are suspected.
What to do
Inform the anesthesia team of fenfluramine use and monitor ECG and blood pressure throughout anesthesia. Treat hypertension or arrhythmia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Sevoflurane?
MediHelp rates the interaction as moderate. Fenfluramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine has serotonergic and sympathomimetic activity and can raise blood pressure. With volatile anesthetics, hemodynamic instability or arrhythmia is theoretically possible, though clinical data are limited.
How serious is the interaction between Fenfluramine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of fenfluramine use and monitor ECG and blood pressure throughout anesthesia. Treat hypertension or arrhythmia promptly.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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