Drug interactions
Fenfluramine + Stiripentol
Severity: Moderate
Fenfluramine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol, given with clobazam, raises fenfluramine exposure because it inhibits several enzymes responsible for fenfluramine clearance. Greater exposure raises the risk of dose-related adverse effects such as decreased appetite, somnolence and cardiovascular effects.
What this interaction means in plain words
Fenfluramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2, CYP2B6 and CYP2D6 metabolism of fenfluramine by stiripentol.
What to do
Limit the fenfluramine dose to the labeled lower maximum when taken with stiripentol plus clobazam. Monitor weight, heart rate and echocardiographic findings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenfluramine and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Fenfluramine with Stiripentol?
MediHelp rates the interaction as moderate. Fenfluramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol, given with clobazam, raises fenfluramine exposure because it inhibits several enzymes responsible for fenfluramine clearance. Greater exposure raises the risk of dose-related adverse effects such as decreased appetite, somnolence and cardiovascular effects.
How serious is the interaction between Fenfluramine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the fenfluramine dose to the labeled lower maximum when taken with stiripentol plus clobazam. Monitor weight, heart rate and echocardiographic findings.
What other medicines interact with Fenfluramine?
MediHelp also lists interactions of Fenfluramine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Fenfluramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
