Drug interactions
Fenfluramine + Vortioxetine
Severity: Major
Fenfluramine and Vortioxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, and combining them raises the risk of serotonin syndrome. Fenfluramine labeling carries a warning about co-use with serotonergic agents.
What this interaction means in plain words
Fenfluramine and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenfluramine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects: fenfluramine releases serotonin and vortioxetine inhibits its reuptake and modulates receptors.
What to do
Avoid the combination when possible; if used, monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, especially at initiation or dose changes. Stop both drugs and treat if serotonin syndrome occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Vortioxetine?
MediHelp rates the interaction as major. Fenfluramine and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs enhance serotonergic activity, and combining them raises the risk of serotonin syndrome. Fenfluramine labeling carries a warning about co-use with serotonergic agents.
How serious is the interaction between Fenfluramine and Vortioxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if used, monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, especially at initiation or dose changes. Stop both drugs and treat if serotonin syndrome occurs.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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